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M9480522.TXT
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1994-08-20
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Document 0522
DOCN M9480522
TI Paromomycin for cryptosporidiosis in AIDS: a prospective, double-blind
trial.
DT 9410
AU White AC Jr; Chappell CL; Hayat CS; Kimball KT; Flanigan TP; Goodgame
RW; Dept. of Medicine, Baylor College of Medicine, Houston, TX 77030.
SO J Infect Dis. 1994 Aug;170(2):419-24. Unique Identifier : AIDSLINE
MED/94308611
AB To test the effects of paromomycin, 10 patients with AIDS and
cryptosporidiosis were randomized to paromomycin or placebo in a
double-blind trial. After 14 days, patients were switched to the other
treatment for 14 additional days. Measures included the number and
character of each stool and weekly 24-h stool specimens for weight and
oocyst excretion. During the paromomycin treatment phase, oocyst
excretion decreased from 314 x 10(6) to 109 x 10(6)24 h (P < .02).
Oocyst excretion increased for the 4 patients initially on placebo
compared to a median decrease of 128 x 10(6)/24 h for the 6 initially
treated with drug (P < .02). Stool frequency also decreased more in
those treated with drug (3.6 fewer vs. 1.25 fewer/24 h, P < .05). Trends
favored drug over placebo for stool weight, stool character, and
Karnofsky score. Paromomycin treatment resulted in improvement in both
clinical and parasitologic parameters in cryptosporidiosis in AIDS.
DE Adult AIDS-Related Opportunistic Infections/*DRUG THERAPY
Cryptosporidiosis/*DRUG THERAPY Diarrhea/DRUG THERAPY Double-Blind
Method Feces/PARASITOLOGY Human Longitudinal Studies Parasite Egg
Count Paromomycin/*THERAPEUTIC USE Prospective Studies Support,
Non-U.S. Gov't CLINICAL TRIAL JOURNAL ARTICLE RANDOMIZED CONTROLLED
TRIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).